NOT MEDICAL ADVICE

PTD-DBM

Estimated Market Price
$129.99 $144.99
Based on verified supplier pricing for research-grade compounds
Hair growth peptide that activates Wnt/beta-catenin signaling. Outperformed minoxidil in studies by stimulating new hair follicle formation.
How it works

Smuggles a Wnt-pathway activator directly into cells, switching on the signaling cascade that creates new hair follicles and pushes existing ones into the active growth phase.

Hair Growth

What to Expect
Week 1–2 Wnt/β-catenin pathway activation initiating in follicles. Nothing visible yet; follicle activation starting deep.
Week 3–4 Dermal papilla cell proliferation increasing; anagen induction. Less hair shedding in the shower; scalp feels healthier.
Week 5–8 Hair follicle neogenesis progressing; new growth visible. Baby hairs appearing; existing hair feels thicker.
Week 9–12 Continued follicle maturation; research endpoint assessment. Visible new growth; hairline or thin spots filling in.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage Preclinical - research doses only
Administration Topical, Subcutaneous injection
Schedule Per research protocol (topical or SC)
Protocol Duration Per research protocol
Half-Life Not well established
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Scalp irritation at application sitesome users

Less Common

  • Mild headacheoccasional
  • Temporary rednessoccasional
  • Itchingoccasional

Discontinue If

  • Severe allergic reaction
  • Signs of abnormal growth
  • Persistent scalp irritation

Contraindications

  • Active scalp cancer or lesions
  • Pregnancy or breastfeeding
  • Known hypersensitivity to Wnt pathway activators

Data note: Wnt pathway activator for hair follicle regeneration. Preclinical compound. Long-term effects of topical Wnt activation are not fully characterized.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about PTD-DBM
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for PTD-DBM

Also Known As PTD-DBM, Protein Transduction Domain-Dishevelled Binding Motif
Classification Cell-Penetrating Peptide · Wnt Activator
Sequence Cell-penetrating peptide fused to Dishevelled-binding motif
Molecular Formula Fusion peptide
Molecular Weight Variable
CAS Number N/A
Half-Life Not well established
Origin Synthetic cell-penetrating peptide designed for Wnt pathway activation
Administration Topical, Subcutaneous injection
Status Research compound - preclinical hair growth studies
Mechanism of Action Smuggles a Wnt-pathway activator directly into cells, switching on the signaling cascade that creates new hair follicles and pushes existing ones into the active growth phase.
Research Overview PTD-DBM (Protein Transduction Domain-Dishevelled Binding Motif) is a synthetic cell-penetrating peptide designed to activate the canonical Wnt/β-catenin signaling pathway for the purpose of promoting hair follicle regeneration and neogenesis. The compound was developed by researchers at Yonsei University in Seoul, South Korea, and represents an innovative peptide engineering approach that combines a cell-penetrating delivery module with a specific pathway-activating payload. The protein transduction domain (PTD) portion - typically derived from the HIV-1 TAT protein or other cell-penetrating peptide sequences - enables the peptide to cross cell membranes through a combination of electrostatic interactions with membrane phospholipids and macropinocytosis, delivering the Dishevelled-binding motif directly into the cytoplasm of target cells. The Dishevelled-binding motif (DBM) portion is designed to interact with Dishevelled (Dvl), a key intracellular signaling protein in the Wnt pathway that transmits signals from Frizzled membrane receptors to downstream effectors. In the canonical Wnt pathway, Dishevelled activation inhibits the GSK-3β/Axin/APC destruction complex, preventing the phosphorylation and proteasomal degradation of β-catenin and allowing it to accumulate in the cytoplasm and translocate to the nucleus where it activates TCF/LEF transcription factors that drive the expression of genes involved in cell proliferation, stem cell maintenance, and tissue morphogenesis. The Wnt/β-catenin pathway plays a critical role in hair follicle biology - it is required for the initiation and maintenance of the anagen (growth) phase of the hair cycle, dermal papilla cell proliferative capacity, and hair follicle neogenesis. Studies published in the Journal of Investigative Dermatology demonstrated that topical application of PTD-DBM promoted hair regrowth in mouse models of alopecia, with histological analysis showing increased hair follicle density, enhanced dermal papilla cell proliferation, and prolonged anagen phase duration.

Citations

Published findings on PTD-DBM from peer-reviewed journals.

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