NOT MEDICAL ADVICE

Biotinoyl Tripeptide-1

Estimated Market Price
$79.99 $94.99
Based on verified supplier pricing for research-grade compounds
Biotin-conjugated hair growth peptide. Strengthens follicle anchoring, reduces shedding, and increases hair density through dermal papilla stimulation.
How it works

Pairs the collagen-boosting GHK peptide with biotin to nourish the dermal papilla at each hair's root. Strengthens hair anchoring, thickens the shaft, and extends the active growth phase.

Hair Growth

What to Expect
Week 1–2 GHK-biotin complex penetrating follicles; dermal papilla activation. Scalp may feel slightly more nourished.
Week 3–4 Hair anchoring strength improving; reduced shedding noticed. Less hair falling out in the brush; shedding reduced.
Week 5–8 Anagen phase extending; new hair growth becoming visible. Hair feels thicker and stronger; new growth starting.
Week 9–12 Thicker hair shafts; fuller appearance with continued use. Visibly fuller hair; less breakage and thinning.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage Topical scalp serum, 2x daily
Administration Topical (scalp application)
Schedule Morning and evening to clean scalp
Protocol Duration 8–12 weeks
Half-Life Topical application
Side Effects & Safety
Tolerability Profile Favorable

Very well tolerated; side effects are rare and mild

Common Side Effects

  • No common side effects reported

Less Common

  • Mild scalp tinglingoccasional
  • Temporary redness at application siteoccasional

Discontinue If

  • Severe allergic reaction or contact dermatitis
  • Persistent scalp irritation

Contraindications

  • Known hypersensitivity to biotin or GHK peptides
  • Active scalp infection or lesions
  • Pregnancy or breastfeeding

Data note: Topical hair-growth peptide combining biotin with GHK. Used in clinical hair care products with favorable tolerability.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Biotinoyl Tripeptide-1
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Biotinoyl Tripeptide-1

Also Known As Biotinoyl-GHK, Biotinyl Tripeptide-1, Procapil®
Classification Biotinylated Peptide · Hair Growth / Cosmetic
Sequence Biotin-Gly-His-Lys
Molecular Formula C₂₆H₃₉N₇O₇S
Molecular Weight 609.72 Da
CAS Number 299157-54-3
Half-Life Topical application
Origin Synthetic biotin-conjugated GHK tripeptide
Administration Topical (scalp application)
Status Commercially available - cosmetic ingredient
Mechanism of Action Pairs the collagen-boosting GHK peptide with biotin to nourish the dermal papilla at each hair's root. Strengthens hair anchoring, thickens the shaft, and extends the active growth phase.
Research Overview Biotinoyl Tripeptide-1 (Biotinyl-GHK) is a synthetic biotinylated peptide consisting of the GHK (Gly-His-Lys) tripeptide conjugated to biotin (vitamin B7/vitamin H) at its N-terminus, developed as a targeted hair care active ingredient and commonly incorporated into the Procapil proprietary complex along with apigenin (a flavonoid) and oleanolic acid (a pentacyclic triterpenoid). The compound was designed to address the multifactorial nature of androgenetic alopecia and age-related hair thinning by combining the well-characterized collagen-stimulating and tissue-remodeling properties of the GHK matrikine peptide with the metabolic cofactor functions of biotin. The GHK portion stimulates extracellular matrix synthesis in the dermal papilla - the mesenchymal signaling center at the base of the hair follicle that controls the hair growth cycle - promoting the structural integrity of the connective tissue sheath that anchors the hair follicle and supports the dermal papilla cell population. Biotin conjugation serves multiple purposes: it enhances the peptide's cellular uptake through biotin transporter-mediated endocytosis (SMVT - sodium-dependent multivitamin transporter), it provides biotin as a cofactor for carboxylase enzymes involved in fatty acid synthesis and amino acid metabolism essential for keratin production, and it improves the stability of the peptide in formulation. In vitro studies on isolated hair follicle cultures demonstrated that Biotinoyl Tripeptide-1 increased the proliferative capacity of dermal papilla cells, enhanced hair shaft keratin production, and prolonged the anagen (growth) phase of the hair cycle. Clinical studies of the Procapil complex (containing Biotinoyl Tripeptide-1 as the lead active) applied topically to the scalp of men with early-stage androgenetic alopecia showed a 46% reduction in hair loss after 4 months and increased hair shaft diameter, with efficacy attributed to the synergistic combination of matrix support (GHK), anti-inflammatory action (apigenin), and DHT metabolism modulation (oleanolic acid).

Citations

Published findings on Biotinoyl Tripeptide-1 from peer-reviewed journals.

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