MGF (Mechano Growth Factor)

Estimated Market Price

$27 – $90

Estimated for 2–5 mg · Based on verified supplier pricing

Locally-acting IGF-1 splice variant that activates muscle satellite cells. First responder in muscle repair, supporting targeted recovery and hypertrophy.

How it works

Released naturally by damaged muscle to wake up satellite cells (muscle stem cells) and multiply them at the injury site. Acts fast and locally because it avoids the binding proteins that slow down regular IGF-1.

Performance

Recovery

What to Expect

Days 1–3 Satellite cell activation at injection site; repair pool expanding. Mild soreness at injection site; targeted area activating.

Week 1–2 Enhanced local recovery; reduced DOMS in targeted muscles. Less soreness after leg day (or targeted muscle).

Week 3–4 Muscle repair capacity significantly boosted; hypertrophy gains. Targeted muscle recovering faster; growth noticeable.

Week 5–6 Peak satellite cell expansion; cycle completing for off-period. Visible size gain in injected muscle groups.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier

LarnaLabs Verified Supplier · larnalabs.com

NXPeptides Verified Supplier · nxpeptides.com

BioSynth Verified Custom Batch Supplier · biosynth.com

Peptide Sciences Unavailable · peptidesciences.com

Protocol & Dosage

Typical Dosage 200–400 mcg near trained muscle on training days

Administration Intramuscular injection (localized)

Schedule Post-workout, localized injection into target muscle

Protocol Duration 4–6 weeks

Half-Life ~5-7 minutes

Side Effects & Safety

Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

Injection site reactionmost users
Mild localized swellingsome users

Less Common

Fatigueoccasional
Headacheoccasional
Mild muscle sorenessoccasional

Discontinue If

Signs of abnormal tissue growth
Persistent swelling beyond injection site
Severe allergic reaction

Contraindications

Active cancer or tumors
Diabetes mellitus (unmonitored)
Pregnancy or breastfeeding

Data note: Mechano Growth Factor — splice variant of IGF-1 expressed after muscle damage. Very short half-life (~minutes). Limited human data.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about MGF (Mechano Growth Factor)

How to Apply

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

Sanitize

Wipe tops of both vials with alcohol swabs

Draw

Pull 1–2 mL of BAC water into syringe

Add Water

Release water slowly along vial wall, not directly on powder

Swirl

Roll between palms until dissolved. Never shake.

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for MGF (Mechano Growth Factor)

Also Known As Mechano Growth Factor, MGF, IGF-1Ec

Classification Growth Factor Fragment · Muscle Repair

Sequence YQPPSTNKNTKSQRRKGS (24 aa C-terminal fragment)

Molecular Formula Peptide (~2.9 kDa)

Molecular Weight ~2,867 Da

CAS Number N/A

Half-Life ~5-7 minutes

Origin Splice variant of IGF-1 gene (Ec isoform), expressed after mechanical load

Administration Intramuscular injection (localized)

Status Research compound

Mechanism of Action Released naturally by damaged muscle to wake up satellite cells (muscle stem cells) and multiply them at the injury site. Acts fast and locally because it avoids the binding proteins that slow down regular IGF-1.

Research Overview Mechano Growth Factor (MGF) is a splice variant of the insulin-like growth factor-1 (IGF-1) gene that is specifically expressed in response to mechanical loading and tissue damage, first characterized by Geoffrey Goldspink and colleagues at University College London. The IGF-1 gene undergoes alternative splicing to produce several distinct mRNA transcripts, with the MGF variant (also known as IGF-1Ec in humans or IGF-1Eb in rodents) featuring a unique C-terminal E-domain extension encoded by exon 5 that is not present in the systemic IGF-1Ea isoform produced by the liver. This unique E-domain peptide - a 24-amino-acid sequence beginning with YQPPSTNKNTKSQRRKGS - represents the biologically distinctive portion of MGF and is the fragment typically used in research applications. The temporal expression pattern of MGF is particularly noteworthy - following muscle damage from exercise or injury, MGF expression peaks within 1-2 hours and returns to baseline within 24 hours, preceding the later, sustained upregulation of IGF-1Ea that continues for days. This rapid, transient expression pattern positions MGF as an early damage-response signal that initiates the repair cascade by activating satellite cells - the resident muscle stem cells located between the sarcolemma and basal lamina of muscle fibers. Crucially, MGF appears to stimulate satellite cell proliferation without promoting their premature differentiation, expanding the pool of repair-competent progenitor cells before the subsequent IGF-1Ea wave drives their differentiation and fusion with existing muscle fibers. The extremely short half-life of the MGF E-domain peptide in circulation (approximately 5-7 minutes) due to rapid enzymatic degradation has presented both a biological rationale and a pharmacological challenge - the brevity of its activity suggests it functions as a strictly local, paracrine signal rather than an endocrine factor, and has motivated the development of PEGylated versions with extended activity.

Citations

Published findings on MGF (Mechano Growth Factor) from peer-reviewed journals.

Mechano Growth Factor E peptide activates human muscle progenitor cells and induces an increase in their fusion potential at different ages

Kandalla PK, et al. • 2011 PubMed

Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration

Matheny RW, et al. • 2010 PubMed

Impairment of IGF-I gene splicing and MGF expression associated with muscle wasting

Goldspink G, Yang SY • 2006 PubMed