NOT MEDICAL ADVICE

Matrixyl

Estimated Market Price
$69.99 $84.99
Based on verified supplier pricing for research-grade compounds
Signal peptide that instructs skin to rebuild collagen and elastin. Clinically proven to nearly double collagen synthesis and reduce wrinkle depth.
How it works

Tricks skin cells into thinking collagen has broken down, prompting them to ramp up production of new collagen, elastin, and other structural proteins. The palmitoyl tail helps it penetrate deeper into the skin.

Skin & Beauty

What to Expect
Week 1–2 TGF-β pathway activated; fibroblast collagen production starting. Skin feels slightly more hydrated and plump.
Week 3–4 Skin firmness improving; fine lines beginning to smooth. Firmness improving; fine lines starting to smooth out.
Week 5–8 Collagen I/III synthesis elevated; visible wrinkle reduction. Visible wrinkle reduction; skin looks younger.
Week 9–12 Peak collagen remodeling; skin texture significantly improved. Skin texture significantly improved; lasting results.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage Topical serum, 2x daily
Administration Topical
Schedule Morning and evening to clean, dry skin
Protocol Duration 4–12 weeks
Half-Life Topical application
Side Effects & Safety
Tolerability Profile Favorable

Very well tolerated; side effects are rare and mild

Common Side Effects

  • No common side effects reported

Less Common

  • Mild skin irritationoccasional
  • Temporary rednessoccasional

Discontinue If

  • Severe allergic reaction or contact dermatitis
  • Persistent skin irritation

Contraindications

  • Known hypersensitivity to palmitoyl peptides
  • Active skin infection at application site
  • Open wounds at application site

Data note: Gold-standard collagen-stimulating peptide in cosmetic dermatology. Decades of safe topical use. No systemic effects.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Matrixyl
Send us a message

Call us
+1 (518) 327-4392
Business hours
Monday – Friday 9:00 AM – 6:00 PM EST
Saturday 10:00 AM – 2:00 PM EST
Sunday Closed

You can also reach us via or .

How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Matrixyl

Also Known As Palmitoyl Pentapeptide-4, Matrixyl®, Pal-KTTKS
Classification Lipopeptide · Collagen Stimulator / Cosmetic
Sequence Pal-Lys-Thr-Thr-Lys-Ser
Molecular Formula C₃₅H₆₆N₆O₈
Molecular Weight 802.05 Da
CAS Number 214047-00-4
Half-Life Topical application
Origin Synthetic lipopeptide based on a procollagen I fragment
Administration Topical
Status Commercially available - cosmetic ingredient
Mechanism of Action Tricks skin cells into thinking collagen has broken down, prompting them to ramp up production of new collagen, elastin, and other structural proteins. The palmitoyl tail helps it penetrate deeper into the skin.
Research Overview Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide cosmeceutical developed by the French company Sederma that consists of the pentapeptide sequence KTTKS (Lys-Thr-Thr-Lys-Ser) conjugated to a palmitic acid (C16) lipid tail, designed to stimulate collagen synthesis in the dermis and reduce the appearance of wrinkles associated with photoaging and chronological skin aging. The KTTKS sequence was identified through research into matrikines - biologically active fragments released during the degradation of extracellular matrix proteins that act as signaling molecules to regulate matrix remodeling. Specifically, KTTKS is a fragment of the C-terminal propeptide of type I procollagen that is cleaved during collagen maturation and acts as a feedback signal to fibroblasts, stimulating new collagen production in a process that represents the skin's natural matrix renewal mechanism. By applying this signaling peptide exogenously, Matrixyl aims to artificially enhance the collagen synthesis response. The palmitoyl tail serves a critical function - it enhances the amphiphilic character of the molecule, dramatically improving penetration through the lipid-rich stratum corneum barrier of the skin and increasing the local concentration of the active peptide in the dermal layer where fibroblasts reside. In vitro studies demonstrated that Matrixyl treatment of cultured human fibroblasts increased the synthesis of collagens I, III, and IV, fibronectin, elastin, and glycosaminoglycans including hyaluronic acid - essentially stimulating the production of the major structural components of the dermal extracellular matrix. The mechanism involves activation of the TGF-β signaling pathway, Smad transcription factor nuclear translocation, and subsequent upregulation of extracellular matrix gene expression. A controlled clinical study published by Robinson and colleagues demonstrated that twice-daily application of a 3% Matrixyl formulation for two months produced statistically significant reductions in wrinkle depth, surface area, and volume compared to placebo, with efficacy approaching that of retinol but with substantially better tolerability and no photosensitization risk.

Citations

Published findings on Matrixyl from peer-reviewed journals.

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