NOT MEDICAL ADVICE

Tat-Beclin-1

Estimated Market Price
$159.99 $174.99
Based on verified supplier pricing for research-grade compounds
Autophagy-inducing peptide for cellular self-cleaning. Activates the same longevity pathway as fasting. Supports metabolic health and neuroprotection.
How it works

Delivers an autophagy-activating payload directly into cells, unlocking Beclin 1 to kick-start the cellular recycling process. Clears out damaged organelles, misfolded proteins, and intracellular debris.

Longevity

Recovery & Longevity

What to Expect
Hours 1–6 Cell-penetrating delivery active; Beclin 1 freed for autophagy. Nothing noticeable; cellular cleanup happening internally.
Day 1–2 Autophagosome formation increasing; cellular recycling ramping up. May feel slightly fatigued as cells recycle.
Day 3–7 Peak autophagic flux; damaged organelles being cleared. Subtle energy boost as damaged components are cleared.
Week 2+ Research assessment period; cellular health markers evaluated.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage Preclinical - research doses (SC or IV)
Administration Subcutaneous injection, Intravenous
Schedule Per research protocol
Protocol Duration Per research protocol
Half-Life Hours
Side Effects & Safety
Tolerability Profile Moderate

Notable side effects likely; manageable with proper awareness

Common Side Effects

  • Injection site reactionmost users

Less Common

  • Fatigueoccasional
  • Mild GI discomfortoccasional
  • Headacheoccasional

Discontinue If

  • Excessive fatigue or malaise (over-autophagy)
  • Signs of organ stress (lab monitoring)
  • Severe allergic reaction

Contraindications

  • Active cancer or tumors
  • Severe immunodeficiency
  • Pregnancy or breastfeeding
  • Concurrent immunosuppressive therapy

Data note: Preclinical autophagy inducer. Excessive autophagy can damage healthy tissue — careful dosing is critical. No human trials published.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Tat-Beclin-1
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Tat-Beclin-1

Also Known As Tat-Beclin 1, TB-1, Tat-Beclin 1 Peptide
Classification Cell-Penetrating Peptide · Autophagy Inducer
Sequence HIV-1 Tat PTD fused to Beclin 1 sequence (18 aa)
Molecular Formula Fusion peptide (~2.0 kDa)
Molecular Weight ~2,000 Da
CAS Number N/A
Half-Life Hours
Origin Synthetic cell-penetrating autophagy-inducing peptide
Administration Subcutaneous injection, Intravenous
Status Research compound - preclinical
Mechanism of Action Delivers an autophagy-activating payload directly into cells, unlocking Beclin 1 to kick-start the cellular recycling process. Clears out damaged organelles, misfolded proteins, and intracellular debris.
Research Overview Tat-Beclin 1 is a synthetic cell-penetrating autophagy-inducing peptide designed to potently activate the cellular self-recycling process of macroautophagy, developed by Beth Levine and colleagues at the University of Texas Southwestern Medical Center. The compound is a fusion of two functional domains - the protein transduction domain from HIV-1 Tat protein (an 11-amino-acid cell-penetrating sequence) linked to a specific region of the autophagy protein Beclin 1 that mediates its interaction with the negative regulator GAPR-1 (Golgi-associated plant pathogenesis-related protein 1, also known as GLIPR2). Autophagy is a fundamental cellular process in which damaged organelles, misfolded protein aggregates, and intracellular pathogens are sequestered within double-membrane autophagosomes and delivered to lysosomes for degradation and recycling of molecular components. Beclin 1 (the mammalian ortholog of yeast Atg6) is a key initiator of autophagosome formation, functioning as part of the Class III PI3K (VPS34) complex that generates phosphatidylinositol 3-phosphate on nascent isolation membranes. However, Beclin 1 activity is tonically suppressed through interactions with multiple negative regulators - including Bcl-2, Bcl-xL, and GAPR-1 - that sequester Beclin 1 in inactive complexes. Tat-Beclin 1 works by competing for the GAPR-1 binding site on endogenous Beclin 1, liberating Beclin 1 from its inhibitory interaction and enabling it to join the VPS34 complex and initiate autophagosome biogenesis. The compound has demonstrated broad-spectrum antiviral activity (against HIV-1, chikungunya virus, West Nile virus, and SARS-CoV-2 in cell culture) by enhancing autophagic degradation of intracellular viral components, anti-tumor effects through autophagic cell death induction in apoptosis-resistant cancer cells, and potential anti-aging effects through enhanced clearance of damaged mitochondria (mitophagy) and protein aggregates that accumulate with age.

Citations

Published findings on Tat-Beclin-1 from peer-reviewed journals.

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