MK-677 (Ibutamoren)

Estimated Market Price

$70 – $100

Estimated for one month supply · Based on verified supplier pricing

Oral growth hormone secretagogue. Boosts GH and IGF-1 levels without injections. Supports lean mass, fat loss, sleep quality, and recovery.

How it works

An oral ghrelin mimetic that keeps growth hormone and IGF-1 elevated for up to 24 hours per dose. Works without injections by activating the same receptor as the hunger hormone ghrelin.

Growth Hormone

Performance

What to Expect

Week 1–2 Increased appetite and dramatically improved sleep quality. Hungry all the time; sleeping like a rock.

Week 3–4 Sustained GH/IGF-1 elevation; recovery and energy improving. Recovery incredible; skin and hair looking better.

Week 5–8 Body composition shift; lean mass up, improved skin quality. Body filling out; leaner with more muscle fullness.

Week 9–12 Peak benefits; bone density and metabolic markers improved. Overall rejuvenation; looking and feeling younger.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier

LarnaLabs Verified Supplier · larnalabs.com

NXPeptides Verified Supplier · nxpeptides.com

BioSynth Verified Custom Batch Supplier · biosynth.com

Peptide Sciences Unavailable · peptidesciences.com

Protocol & Dosage

Typical Dosage 10–25 mg oral at night

Administration Oral

Schedule Once daily at bedtime

Protocol Duration 8–12 weeks on, then off

Half-Life ~24 hours (oral bioavailability)

Side Effects & Safety

Tolerability Profile Moderate

Notable side effects likely; manageable with proper awareness

Common Side Effects

Increased appetite~70%
Water retention and bloatingmost users
Mild joint stiffnesssome users
Morning lethargysome users
Vivid dreamssome users

Less Common

Elevated fasting blood sugar10–15%
Tingling or numbnessoccasional
Muscle painoccasional
Increased cortisol (mild)occasional

Rare / Serious

Insulin resistance (long-term use)rare
Persistent edemarare
Carpal tunnel syndromerare

Discontinue If

Signs of diabetes (persistent elevated blood sugar, increased thirst)
Carpal tunnel symptoms (hand numbness, weakness)
Persistent edema (face, hands, ankles)
Shortness of breath (fluid retention)

Contraindications

Active cancer or tumors
Diabetes mellitus
Pregnancy or breastfeeding
Pituitary tumor

Data note: Oral GH secretagogue (not a peptide). 2-year clinical trial exists showing significant blood sugar elevation — fasting glucose monitoring is essential.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about MK-677 (Ibutamoren)

How to Apply

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

Sanitize

Wipe tops of both vials with alcohol swabs

Draw

Pull 1–2 mL of BAC water into syringe

Add Water

Release water slowly along vial wall, not directly on powder

Swirl

Roll between palms until dissolved. Never shake.

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for MK-677 (Ibutamoren)

Also Known As Ibutamoren, MK-0677, Nutrobal, Oratrope

Classification Small Molecule · Non-Peptide GH Secretagogue

Sequence N/A (non-peptide small molecule)

Molecular Formula C₂₇H₃₆N₄O₅S

Molecular Weight 528.67 Da

CAS Number 159752-10-0

Half-Life ~24 hours (oral bioavailability)

Origin Synthetic non-peptide ghrelin receptor agonist (Merck)

Administration Oral

Status Research compound - Phase II clinical trials

Mechanism of Action An oral ghrelin mimetic that keeps growth hormone and IGF-1 elevated for up to 24 hours per dose. Works without injections by activating the same receptor as the hunger hormone ghrelin.

Research Overview Ibutamoren (MK-677), developed by Merck & Co. under the designation MK-0677, is a non-peptide spiropiperidine compound that mimics the action of ghrelin at the growth hormone secretagogue receptor (GHS-R1a) with the crucial advantage of oral bioavailability - a property that distinguishes it from all peptide-based growth hormone secretagogues which require parenteral administration. First described in the scientific literature in the mid-1990s, MK-677 emerged from a high-throughput screening program at Merck designed to identify small molecules capable of activating the then-orphan GHS receptor. The compound produces sustained elevation of growth hormone and IGF-1 levels for approximately 24 hours following a single oral dose, reflecting its long plasma half-life of 4-6 hours combined with continued GH pulsatility enhancement. Clinical studies demonstrated that 25 mg daily oral dosing increased GH pulse amplitude by approximately 80% and 24-hour mean GH concentration by 97% in healthy young men, while in elderly subjects, MK-677 restored GH and IGF-1 levels to those characteristic of young adults. A two-year clinical trial in elderly subjects showed significant improvements in lean body mass and bone mineral density without changes in visceral fat, along with improved sleep quality - particularly an increase in stage IV (deep) sleep duration and REM sleep. The ghrelin-mimetic nature of MK-677 also produces appetite stimulation (through hypothalamic GHS-R1a activation), which is a dose-limiting factor for some users but potentially beneficial in conditions of muscle wasting, cachexia, or age-related anorexia. Notable side effects include transient water retention, increased fasting blood glucose (reflecting GH's counter-regulatory effects on insulin), and joint stiffness. Despite completing multiple Phase II clinical trials with positive results for sarcopenia, hip fracture recovery, and growth hormone deficiency, MK-677 has not yet received FDA approval for any indication.

Citations

Published findings on MK-677 (Ibutamoren) from peer-reviewed journals.

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism

Murphy MG, et al. • 1998 PubMed

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

Nass R, et al. • 2008 PubMed

Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women

Khorram O, et al. • 1997 PubMed