NOT MEDICAL ADVICE

Kisspeptin-10

Estimated Market Price
$22 $124
Estimated for 5–10 mg · Based on verified supplier pricing
Master regulator of the hormonal axis. Stimulates natural testosterone production and enhances sexual arousal without HPG axis suppression.
How it works

Flips the master switch of the reproductive hormone cascade by activating kisspeptin receptors in the hypothalamus, which triggers GnRH release and downstream LH/FSH production.

Performance

Sexual Health

What to Expect
0–15 min GPR54 activation; GnRH pulse initiated from hypothalamus. Warmth spreading; subtle hormonal shift felt.
15–60 min LH and FSH surge measurable in bloodwork. May notice increased energy or slight arousal.
1–4 hours Peak hormonal response; diagnostic window for assessment. Effects at their peak; hormonal response active.
24 hours Hormonal levels returning to baseline; results interpreted. Back to baseline; results visible in follow-up labs.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 100–200 mcg SC daily or as needed
Administration Intravenous, Subcutaneous injection
Schedule Daily or as-needed in short cycles
Protocol Duration Short cycles, 1–2 weeks; professional guidance recommended
Half-Life ~4 minutes
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Injection site reactionmost users
  • Mild flushing or warmthsome users

Less Common

  • Headacheoccasional
  • Temporary mood shiftsoccasional
  • Hot flashesoccasional
  • Abdominal discomfortoccasional

Discontinue If

  • Severe hormonal symptoms (persistent hot flashes, mood changes)
  • Signs of hormonal imbalance (menstrual irregularity)
  • Severe allergic reaction

Contraindications

  • Hormone-sensitive cancers
  • Pregnancy or breastfeeding
  • Precocious puberty (in minors)

Data note: Endogenous neuropeptide that regulates reproductive hormones. Clinical research in IVF and reproductive medicine shows favorable tolerability.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Kisspeptin-10
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Kisspeptin-10

Also Known As Kisspeptin-10, KP-10, Metastin(45-54)
Classification Decapeptide · Reproductive Hormone Regulator
Sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (10 aa)
Molecular Formula C₆₃H₈₃N₁₇O₁₄
Molecular Weight 1,302.45 Da
CAS Number 374675-21-5
Half-Life ~4 minutes
Origin C-terminal fragment of kisspeptin-54 (metastin)
Administration Intravenous, Subcutaneous injection
Status Research · Clinical trials for reproductive disorders
Mechanism of Action Flips the master switch of the reproductive hormone cascade by activating kisspeptin receptors in the hypothalamus, which triggers GnRH release and downstream LH/FSH production.
Research Overview Kisspeptin-10 (KP-10) is a decapeptide representing the minimal bioactive C-terminal fragment of kisspeptin-54 (also known as metastin), a peptide encoded by the KISS1 gene that has been identified as the master upstream regulator of the hypothalamic-pituitary-gonadal reproductive axis. The kisspeptin system was discovered through a convergence of cancer biology and reproductive endocrinology - KISS1 was originally identified as a metastasis suppressor gene in melanoma (hence the alternative name "metastin"), and its critical role in reproduction was subsequently revealed by the 2003 discovery that loss-of-function mutations in the kisspeptin receptor GPR54 (KISS1R) cause hypogonadotropic hypogonadism - the failure of puberty onset - in both humans and mice. Kisspeptin neurons in the hypothalamus, concentrated in the arcuate nucleus (ARC) and the anteroventral periventricular nucleus (AVPV), project directly to GnRH neurons and provide the essential stimulatory signal for pulsatile gonadotropin-releasing hormone secretion. Kisspeptin-10 activates KISS1R with the same affinity as the full-length kisspeptin-54, triggering robust release of GnRH which in turn stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. Clinical research led by Waljit Dhillo at Imperial College London demonstrated that kisspeptin-10 infusion in healthy men and women produced dose-dependent increases in LH and FSH secretion, establishing the translational validity of the kisspeptin system as a therapeutic target. In reproductive medicine, kisspeptin-10 is being investigated as an alternative to GnRH agonist triggers in IVF protocols to induce oocyte maturation with dramatically lower risk of ovarian hyperstimulation syndrome (OHSS), and as a diagnostic tool for differentiating hypothalamic from pituitary causes of reproductive dysfunction.

Citations

Published findings on Kisspeptin-10 from peer-reviewed journals.

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