NOT MEDICAL ADVICE

Sermorelin

Estimated Market Price
$35 $90
Estimated for 5–10 mg vial · Based on verified supplier pricing
Synthetic GHRH analog that stimulates natural growth hormone release. Widely used for anti-aging, sleep improvement, body composition, and long-term GH optimization.
How it works

A bioidentical fragment of your natural growth hormone-releasing hormone that stimulates the pituitary to produce GH in its normal pulsatile pattern, preserving your body's built-in feedback regulation.

Growth Hormone

Recovery & Longevity

What to Expect
Week 1–2 Pulsatile GH release restored; improved sleep quality. Sleep improving; falling asleep faster, waking less.
Week 3–4 Recovery and energy levels increasing noticeably. More energy and better recovery after exercise.
Month 2–3 Body composition improving; skin and hair quality better. Skin improving; body slowly getting leaner and tighter.
Month 4–6 Full anti-aging GH optimization; labs to confirm levels. Feeling years younger; vitality and appearance much better.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 100–300 mcg SC nightly
Administration Subcutaneous injection
Schedule 30 min before bedtime, fasted; 5–7 nights/week
Protocol Duration 3–6 months
Half-Life ~10-20 minutes
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Injection site redness or painmost users
  • Mild flushingsome users
  • Headachesome users

Less Common

  • Water retentionoccasional
  • Dizzinessoccasional
  • Hyperactivity or restlessnessoccasional
  • Temporary nauseaoccasional

Discontinue If

  • Persistent headache
  • Signs of elevated blood sugar
  • Swelling in hands or feet (edema)

Contraindications

  • Active cancer or tumors
  • Diabetic retinopathy
  • Pregnancy or breastfeeding

Data note: Previously FDA-approved (Geref, 1997-2008; discontinued for commercial reasons). Established safety profile from clinical use.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Sermorelin
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Sermorelin

Also Known As Geref, GRF(1-29)NH₂, Sermorelin Acetate
Classification GHRH Analog · Growth Hormone Releasing
Sequence Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ (29 aa)
Molecular Formula C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight 3,357.88 Da
CAS Number 86168-78-7
Half-Life ~10-20 minutes
Origin Synthetic truncated form of natural GHRH(1-44)
Administration Subcutaneous injection
Status Previously FDA Approved (withdrawn 2008 for commercial reasons)
Mechanism of Action A bioidentical fragment of your natural growth hormone-releasing hormone that stimulates the pituitary to produce GH in its normal pulsatile pattern, preserving your body's built-in feedback regulation.
Research Overview Sermorelin is a synthetic 29-amino-acid peptide representing the shortest fully functional fragment of human growth hormone-releasing hormone (GHRH) that retains complete biological activity at the GHRH receptor. Originally developed by scientists at Tulane University and subsequently manufactured by Serono Laboratories, sermorelin was approved by the FDA in 1997 under the trade name Geref for the diagnosis and treatment of growth hormone deficiency in children, making it one of the few GHRH analogs to achieve full regulatory approval for clinical use in the United States. The compound is a bioidentical truncation of the native 44-amino-acid GHRH peptide, containing amino acids 1-29 which encompass the complete receptor-binding domain - research demonstrated that residues 30-44 of native GHRH are not required for receptor binding or signal transduction but contribute to conformational stability. Sermorelin binds to GHRH receptors on anterior pituitary somatotroph cells, activating the Gs-protein/adenylyl cyclase/cAMP signaling cascade that stimulates GH gene transcription, GH synthesis, and episodic GH release. A critical pharmacological advantage of sermorelin over exogenous GH administration is its preservation of the body's natural feedback regulation - the pituitary response to GHRH is modulated by somatostatin, IGF-1, and GH itself through negative feedback, meaning that sermorelin-stimulated GH release is self-limiting and cannot produce the supraphysiological GH levels associated with exogenous GH injection. Although sermorelin was voluntarily withdrawn from the commercial market in 2008 by EMD Serono for business reasons (not safety concerns), it remains available through compounding pharmacies and continues to be widely used in age-management medicine. Clinical research demonstrated that sermorelin treatment in adults with age-related GH decline improved body composition, skin thickness, bone mineral density, and markers of immune function over 6-12 month treatment periods.

Citations

Published findings on Sermorelin from peer-reviewed journals.

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