NOT MEDICAL ADVICE

Dihexa

Estimated Market Price
$119.99 $134.99
Based on verified supplier pricing for research-grade compounds
Synthetic hexapeptide derived from angiotensin IV. Potent HGF receptor agonist studied in neuroscience for synaptic connectivity and neurotrophic signaling.
How it works

Activates the HGF/MET receptor system in the hippocampus to massively boost the formation of new synaptic connections. This strengthens memory encoding and recall at an extraordinarily high potency.

Focus & Cognition

What to Expect
Days 1–3 HGF/MET receptor binding initiating; subtle alertness increase. Subtle alertness boost; might not notice much yet.
Week 1–2 Synaptic connectivity improving; enhanced memory recall. Memory recall improving; names and details come easier.
Week 3–4 Spinogenesis and LTP optimized; cognitive gains consolidating. Learning feels faster; mental connections forming quicker.
Week 5–8 Peak nootropic effects; significant learning and recall boost. Cognitive performance at its best; thinking feels effortless.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 1–10 mg oral or intranasal daily
Administration Subcutaneous injection, Oral (under investigation)
Schedule Once daily, AM on empty stomach
Protocol Duration 4–8 weeks
Half-Life Not well established
Side Effects & Safety
Tolerability Profile Moderate

Notable side effects likely; manageable with proper awareness

Common Side Effects

  • Mild headachesome users
  • Vivid or intense dreamssome users

Less Common

  • Temporary restlessnessoccasional
  • Insomniaoccasional
  • Mild anxietyoccasional
  • GI discomfortoccasional

Rare / Serious

  • Overstimulation (racing thoughts)rare

Discontinue If

  • Severe or persistent headache
  • Persistent anxiety or agitation
  • Signs of overstimulation (racing heart, inability to calm down)

Contraindications

  • Active cancer (HGF/MET pathway promotes cell growth)
  • Pregnancy or breastfeeding
  • Uncontrolled seizure disorder

Data note: Picomolar-potency compound with NO human clinical trials. HGF/MET activation is a known oncogenic pathway. Extreme caution warranted.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Dihexa
Send us a message

Call us
+1 (518) 327-4392
Business hours
Monday – Friday 9:00 AM – 6:00 PM EST
Saturday 10:00 AM – 2:00 PM EST
Sunday Closed

You can also reach us via or .

How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Dihexa

Also Known As N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408
Classification Modified Oligopeptide · Nootropic
Sequence Hexanoyl-Tyr-Ile-Ahx-NHâ‚‚ (modified tripeptide)
Molecular Formula C₂₄H₃₇N₃O₇S
Molecular Weight 507.60 Da
CAS Number 1401708-83-5
Half-Life Not well established
Origin Derived from angiotensin IV metabolites
Administration Subcutaneous injection, Oral (under investigation)
Status Research compound - preclinical
Mechanism of Action Activates the HGF/MET receptor system in the hippocampus to massively boost the formation of new synaptic connections. This strengthens memory encoding and recall at an extraordinarily high potency.
Research Overview Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a modified oligopeptide analog of angiotensin IV that has generated intense interest in cognitive enhancement research following the striking claim by its discoverers that it is approximately 10 million times more potent than brain-derived neurotrophic factor (BDNF) at enhancing synaptogenesis. Developed by Joseph Harding and John Wright at Washington State University, dihexa emerged from decades of research into the renin-angiotensin system's role in cognitive function - specifically the observation that angiotensin IV and its metabolites could enhance memory and learning when administered to experimental animals. The key breakthrough was the identification that these cognitive effects were mediated not through classical angiotensin receptors but through the hepatocyte growth factor (HGF) and its receptor c-Met (MET), a tyrosine kinase receptor system previously known primarily for its roles in embryonic development, tissue repair, and cancer biology. Dihexa was engineered as a stable, blood-brain barrier-permeable small peptide that directly activates the HGF/MET signaling cascade in the hippocampus and cortex, promoting spinogenesis (the formation of new dendritic spines), synaptogenesis, and long-term potentiation - the cellular mechanism underlying memory consolidation. In behavioral studies, dihexa-treated aged rats showed restoration of cognitive function to levels comparable to young adults across multiple memory paradigms including the Morris water maze, novel object recognition, and radial arm maze. The compound also demonstrated the ability to rescue cognitive deficits in a scopolamine-induced amnesia model, suggesting relevance to cholinergic dysfunction in Alzheimer's disease. A patent was filed for dihexa as a potential treatment for neurodegenerative conditions, though clinical development has progressed slowly. The compound remains in preclinical research stages, with the scientific community awaiting independent replication of the remarkable potency claims and further characterization of the long-term safety profile.

Citations

Published findings on Dihexa from peer-reviewed journals.

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