NOT MEDICAL ADVICE

Ipamorelin

Estimated Market Price
$21 $80
Estimated for 5–10 mg · Based on verified supplier pricing
Growth hormone secretagogue for clean GH release without cortisol or prolactin spikes. The safest GH peptide available.
How it works

Triggers growth hormone release from the pituitary by activating ghrelin receptors, but unlike other GH secretagogues, it does so cleanly without spiking cortisol, hunger, or prolactin.

Growth Hormone

Performance

popular

What to Expect
Week 1–2 GH pulses amplified; deeper sleep onset noticed quickly. Falling asleep faster; sleep feels much deeper.
Week 3–4 Recovery between workouts improving; mild fat redistribution. Less sore after workouts; subtle fat loss starting.
Week 5–8 Lean body mass gains visible; skin elasticity improving. Skin looks healthier; body getting leaner.
Week 9–12 Peak selective GH benefits; no cortisol or appetite issues. Overall rejuvenation; energy and recovery excellent.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 200–300 mcg SC, 1–2 times daily (fasted)
Administration Subcutaneous injection
Schedule 1–2x daily fasted; 5 days on / 2 days off
Protocol Duration 5 days on / 2 off for 8–12 weeks
Half-Life ~2 hours
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Injection site rednessmost users
  • Mild water retentionsome users
  • Vivid dreamssome users

Less Common

  • Headacheoccasional
  • Mild joint stiffnessoccasional
  • Temporary lightheadednessoccasional

Discontinue If

  • Carpal tunnel symptoms (hand numbness, tingling)
  • Persistent joint swelling
  • Signs of elevated blood sugar

Contraindications

  • Active cancer or tumors
  • Diabetic retinopathy
  • Pregnancy or breastfeeding

Data note: Cleanest GH secretagogue studied — does NOT raise cortisol, prolactin, or appetite (unlike GHRP-6). Phase II trial data available.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Ipamorelin
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Ipamorelin

Also Known As NNC 26-0161, Ipamorelin Acetate
Classification Pentapeptide · Growth Hormone Secretagogue
Sequence Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Molecular Formula C₃₈H₄₉N₉O₅
Molecular Weight 711.85 Da
CAS Number 170851-70-4
Half-Life ~2 hours
Origin Synthetic growth hormone secretagogue
Administration Subcutaneous injection
Status Research compound · Phase II clinical trials
Mechanism of Action Triggers growth hormone release from the pituitary by activating ghrelin receptors, but unlike other GH secretagogues, it does so cleanly without spiking cortisol, hunger, or prolactin.
Research Overview Ipamorelin is a synthetic pentapeptide growth hormone secretagogue developed by Novo Nordisk in the late 1990s that distinguished itself from earlier GHRPs by its unprecedented selectivity for growth hormone release. First characterized by Raun and colleagues in a 1998 publication in the European Journal of Endocrinology, ipamorelin was derived from a systematic medicinal chemistry program that screened thousands of modified pentapeptide analogs for optimal GHS receptor (ghrelin receptor) binding with minimal off-target activity. The result was a compound that, unlike its predecessors GHRP-6 and GHRP-2, stimulates growth hormone secretion from the pituitary without causing significant elevation of cortisol, aldosterone, prolactin, or ACTH - even at doses many times higher than those required for maximal GH release. This selectivity profile is unique among growth hormone secretagogues and has been attributed to ipamorelin's specific binding characteristics at the GHS-R1a receptor, which appear to activate downstream signaling cascades preferentially coupled to GH release rather than the broader neuroendocrine activation seen with less selective ghrelin mimetics. In bone metabolism research, ipamorelin has demonstrated particularly promising results - studies by Svensson and colleagues showed significant increases in bone mineral content and bone formation markers in adult female rats, while research by Andersen and colleagues demonstrated that ipamorelin could counteract glucocorticoid-induced decreases in bone formation, suggesting potential applications in osteoporosis prevention. The peptide also showed positive results in gastrointestinal motility research, with a clinical trial demonstrating acceleration of gastric emptying in post-operative ileus patients. Its favorable safety profile, lack of appetite stimulation (unlike GHRP-6), and absence of cortisol elevation have made ipamorelin one of the most extensively researched growth hormone secretagogues in both clinical and research settings.

Citations

Published findings on Ipamorelin from peer-reviewed journals.

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