NOT MEDICAL ADVICE

Palmitoyl Tripeptide-5 (Syn-Coll)

Estimated Market Price
$69.99 – $84.99
Based on verified supplier pricing for research-grade compounds
TGF-beta pathway activator for collagen synthesis. Mimics thrombospondin-1 to stimulate type I collagen production and improve skin firmness.
How it works

Mimics a natural matrix protein to activate TGF-beta, which both ramps up new collagen production and blocks the enzymes (MMPs) that break down existing collagen. A build-and-protect approach.

Skin & Beauty

What to Expect
Week 1–2 TGF-β activation and MMP inhibition beginning simultaneously. Subtle hydration boost; skin adjusting to the peptide.
Week 3–4 Collagen production rising while degradation is blocked. Skin starting to feel firmer and more resilient.
Week 5–8 Dual build-and-protect mechanism fully active; firmer skin. Wrinkles softening; skin looks tighter and more elastic.
Week 9–12 Peak collagen density; visible anti-aging transformation. Collagen rebuild visible; skin texture much improved.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage Topical serum, 2x daily
Administration Topical
Schedule Morning and evening to clean, dry skin
Protocol Duration 8–12 weeks
Half-Life Topical application
Side Effects & Safety
Tolerability Profile Favorable

Very well tolerated; side effects are rare and mild

Common Side Effects

  • No common side effects reported

Less Common

  • Mild skin sensitivityoccasional
  • Temporary rednessoccasional

Discontinue If

  • Severe allergic reaction
  • Persistent irritation

Contraindications

  • Known hypersensitivity to lipopeptides
  • Active skin infection at application site
  • Open wounds at application site

Data note: TGF-β mimetic peptide for collagen synthesis. Topical cosmetic ingredient with excellent safety profile.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Palmitoyl Tripeptide-5 (Syn-Coll)
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Palmitoyl Tripeptide-5 (Syn-Coll)

Also Known As Pal-KVK, SYN®-COLL
Classification Lipopeptide · Collagen Stimulator / Cosmetic
Sequence Pal-Lys-Val-Lys
Molecular Formula C₃₂H₆₂N₄O₅
Molecular Weight 595.84 Da
CAS Number 623172-56-5
Half-Life Topical application
Origin Synthetic lipopeptide - thrombospondin-1 mimetic
Administration Topical
Status Commercially available - cosmetic ingredient
Mechanism of Action Mimics a natural matrix protein to activate TGF-beta, which both ramps up new collagen production and blocks the enzymes (MMPs) that break down existing collagen. A build-and-protect approach.
Research Overview Palmitoyl Tripeptide-5 (Pal-KVK, marketed as SYN-COLL by DSM) is a synthetic lipopeptide consisting of the tripeptide Lys-Val-Lys conjugated to a palmitic acid tail, designed to stimulate collagen production through a mechanism that mimics the action of thrombospondin-1 (TSP-1), a large multifunctional extracellular matrix glycoprotein involved in wound healing, angiogenesis regulation, and tissue remodeling. The KVK tripeptide sequence corresponds to a specific domain within thrombospondin-1 that is responsible for activating latent TGF-β (transforming growth factor-beta), the master regulator of extracellular matrix synthesis in the skin. In normal physiology, TGF-β is secreted by cells in an inactive latent form bound to the latency-associated peptide (LAP) and must be activated by proteolytic or conformational mechanisms before it can bind its cell surface receptors. Thrombospondin-1 is one of the most important physiological activators of latent TGF-β, and the specific activation motif has been localized to a sequence that the KVK peptide mimics. Upon TGF-β activation and receptor binding, a signaling cascade is initiated through Smad2 and Smad3 phosphorylation, nuclear translocation, and transcriptional activation of genes encoding collagens I, III, and IV, fibronectin, and other matrix components. Simultaneously, TGF-β signaling suppresses the expression of matrix metalloproteinases (MMPs) - enzymes responsible for collagen degradation - creating a dual mechanism that both promotes new collagen synthesis and protects existing collagen from enzymatic breakdown. This "build and protect" approach distinguishes Palmitoyl Tripeptide-5 from purely synthesis-stimulating peptides. In vitro assays demonstrated that the peptide increases collagen I synthesis by up to 119% at optimal concentrations, while clinical studies showed statistically significant improvements in wrinkle depth, skin firmness, and overall photodamage scores after 84 days of twice-daily application.

Citations

Published findings on Palmitoyl Tripeptide-5 (Syn-Coll) from peer-reviewed journals.

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