NOT MEDICAL ADVICE

VIP (Vasoactive Intestinal Peptide)

Estimated Market Price
$124.99 $139.99
Based on verified supplier pricing for research-grade compounds
Anti-inflammatory neuropeptide used for CIRS and mold illness. Regulates cytokines, supports gut barrier integrity, and provides neuroprotection.
How it works

Activates VIP receptors throughout the body to widen blood vessels, open airways, calm inflammation, and regulate circadian rhythms. Also promotes immune tolerance by encouraging regulatory T-cell development.

Immune Support

Recovery

What to Expect
Days 1–3 VPAC receptor activation; bronchodilation and calming onset. Breathing may feel easier; subtle calming effect.
Week 1–2 Anti-inflammatory cascade active; respiratory function improving. Respiratory comfort improving; less nasal congestion.
Week 3–6 Circadian rhythm normalization; systemic inflammation declining. Sleep schedule normalizing; inflammation symptoms reducing.
Week 7–12 Peak immunomodulatory and vasodilatory benefits sustained. Breathing, sleep, and energy sustainably better.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 50–100 mcg intranasal, 2–3x daily
Administration Intravenous, Intranasal, Subcutaneous injection
Schedule 2–3x daily; spaced evenly throughout the day
Protocol Duration 4–12 weeks
Half-Life ~1-2 minutes
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Facial flushingmost users
  • Transient hypotension (blood pressure drop)some users
  • Mild tachycardiasome users

Less Common

  • Diarrheaoccasional
  • Abdominal crampingoccasional
  • Headacheoccasional
  • Dizzinessoccasional

Discontinue If

  • Severe hypotension (lightheadedness, fainting)
  • Persistent or watery diarrhea
  • Cardiac symptoms (chest pain, irregular heartbeat)

Contraindications

  • Severe hypotension
  • Active diarrheal illness
  • Pregnancy or breastfeeding
  • VIPoma (VIP-secreting tumor)

Data note: Endogenous neuropeptide with potent vasodilatory effects. Side effects are largely pharmacological (vasodilation-related) and dose-dependent.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about VIP (Vasoactive Intestinal Peptide)
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for VIP (Vasoactive Intestinal Peptide)

Also Known As Vasoactive Intestinal Peptide, VIP, RG-100
Classification Neuropeptide · Vasodilator / Immunomodulator
Sequence His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn (28 aa)
Molecular Formula C₁₄₇H₂₃₈N₄₄O₄₃S
Molecular Weight 3,326.82 Da
CAS Number 37221-79-7
Half-Life ~1-2 minutes
Origin Naturally produced by neurons in gut, pancreas, and brain
Administration Intravenous, Intranasal, Subcutaneous injection
Status Research · Clinical trials for pulmonary conditions
Mechanism of Action Activates VIP receptors throughout the body to widen blood vessels, open airways, calm inflammation, and regulate circadian rhythms. Also promotes immune tolerance by encouraging regulatory T-cell development.
Research Overview Vasoactive intestinal peptide (VIP) is a 28-amino-acid neuropeptide belonging to the glucagon/secretin superfamily that was first isolated from porcine duodenal extracts by Sami Said and Viktor Mutt in 1970 and named for its potent vasodilatory activity observed during initial characterization. Subsequent research revealed VIP to be far more than a gut hormone - it is now recognized as a widely distributed neurotransmitter and neuromodulator found throughout the central and peripheral nervous systems, with particularly dense expression in parasympathetic neurons innervating the lungs, heart, gastrointestinal tract, and cerebral vasculature. VIP signals through two G-protein-coupled receptors, VPAC1 and VPAC2, both of which are linked to adenylyl cyclase activation and cAMP generation, though they differ in tissue distribution and downstream signaling nuances. In the cardiovascular system, VIP is one of the most potent endogenous vasodilators known, producing smooth muscle relaxation in both systemic and pulmonary vascular beds through cAMP-mediated and nitric oxide-dependent mechanisms. In the respiratory system, VIP functions as a bronchodilator and plays a critical role in maintaining airway tone, with evidence that VIP deficiency may contribute to the pathophysiology of pulmonary arterial hypertension and asthma. In the gastrointestinal tract, VIP stimulates pancreatic bicarbonate and water secretion, inhibits gastric acid production, promotes smooth muscle relaxation, and regulates intestinal epithelial ion transport. Perhaps most remarkably from a therapeutic perspective, VIP possesses potent anti-inflammatory and immunomodulatory properties - it suppresses the production of TNF-α, IL-6, IL-12, and other pro-inflammatory cytokines from macrophages and dendritic cells, inhibits NF-κB activation, and promotes the generation of regulatory T cells (Tregs) that maintain immune tolerance. These immunomodulatory properties have generated research interest in VIP as a potential treatment for autoimmune conditions, with preclinical studies showing efficacy in models of rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and graft-versus-host disease.

Citations

Published findings on VIP (Vasoactive Intestinal Peptide) from peer-reviewed journals.

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