NOT MEDICAL ADVICE

Epithalon

Estimated Market Price
$119.99 $134.99
Based on verified supplier pricing for research-grade compounds
Telomerase-activating peptide for cellular longevity and anti-aging. The premier longevity peptide, backed by decades of research.
How it works

Turns on telomerase, the enzyme that rebuilds the protective caps on your chromosomes that naturally shorten as you age. Also boosts melatonin production from the pineal gland.

Anti-Aging

Recovery & Longevity

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What to Expect
Days 1–3 Telomerase activation begins at cellular level. Most people feel nothing specific yet.
Days 4–10 Improved sleep quality from melatonin upregulation. Falling asleep easier; sleep feels deeper and more restful.
Days 11–15 Telomere elongation measurable in some cell lines. Waking up more refreshed; subtle energy improvement.
Days 16–20 Cycle complete; neuroendocrine benefits consolidating. General sense of well-being; feeling "younger" is common.
Month 2–6 Off-cycle maintenance; repeat protocol as scheduled. Benefits persist between cycles; sleep quality maintained.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 5–10 mg/day SC
Administration Subcutaneous injection, Intravenous
Schedule Once daily for 10–20 day cycles; repeat every 4–6 months
Protocol Duration 10–20 day cycles
Half-Life ~4 hours
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Injection site rednessmost users
  • Mild drowsiness (melatonin upregulation)some users

Less Common

  • Vivid or unusual dreamsoccasional
  • Headacheoccasional
  • Morning grogginessoccasional
  • Temporary fatigueoccasional

Discontinue If

  • Severe allergic reaction (swelling, hives)
  • Persistent excessive sleepiness
  • Mood changes or depression

Contraindications

  • Active cancer or tumors (telomerase activation concern)
  • Autoimmune thyroid conditions
  • Pregnancy or breastfeeding

Data note: Studied primarily by Russian researchers (Khavinson group). Safety data from animal longevity studies; limited Western clinical trials.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Epithalon
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Epithalon

Also Known As Epitalon, Epithalamin, AEDG Peptide
Classification Tetrapeptide · Telomerase Activator
Sequence Ala-Glu-Asp-Gly
Molecular Formula C₁₄H₂₂N₄O₉
Molecular Weight 390.35 Da
CAS Number 307297-39-8
Half-Life ~4 hours
Origin Synthetic tetrapeptide based on natural epithalamin from pineal gland
Administration Subcutaneous injection, Intravenous
Status Research · Preclinical / early clinical studies
Mechanism of Action Turns on telomerase, the enzyme that rebuilds the protective caps on your chromosomes that naturally shorten as you age. Also boosts melatonin production from the pineal gland.
Research Overview Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology in Russia as part of a decades-long research program into peptide bioregulators - short peptides hypothesized to regulate gene expression in specific tissues. Epithalon was designed as a synthetic analog of epithalamin, a polypeptide extract derived from the bovine pineal gland that had demonstrated lifespan-extending properties in rodent studies conducted throughout the 1980s and 1990s. The primary mechanism of interest is epithalon's ability to activate telomerase, the ribonucleoprotein enzyme responsible for adding TTAGGG nucleotide repeats to the ends of chromosomes. Telomere shortening occurs with each cell division and is considered a fundamental mechanism of cellular aging - when telomeres reach a critical minimum length, cells enter replicative senescence and cease dividing. In vitro studies published in the Bulletin of Experimental Biology and Medicine demonstrated that epithalon treatment induced telomerase activity in human fetal fibroblasts and pulmonary endothelial cells, resulting in measurable telomere elongation beyond the normal replicative limit. Animal longevity studies conducted by Khavinson's group in multiple mouse and rat strains showed statistically significant increases in mean and maximum lifespan, with treated animals showing a 31% increase in mean lifespan in some experimental groups. The peptide's effects on the pineal gland are also noteworthy - epithalon stimulates melatonin production and helps restore the circadian rhythm of melatonin secretion that deteriorates with age, which may contribute to its broader anti-aging effects given melatonin's roles in antioxidant defense, immune regulation, and sleep architecture. While these results are compelling, it should be noted that the majority of published research originates from Russian laboratories, and large-scale, independent replication studies by Western research groups remain limited.

Citations

Published findings on Epithalon from peer-reviewed journals.

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