HGH Fragment 176-191

Estimated Market Price

$99.99 – $114.99

Based on verified supplier pricing for research-grade compounds

The fat-burning fragment of human growth hormone. Stimulates lipolysis and inhibits fat storage without affecting blood sugar or insulin sensitivity.

How it works

The specific slice of growth hormone responsible for fat burning, isolated from the rest. Tells fat cells to break down stored fat and stop making new fat, without affecting muscle growth, blood sugar, or IGF-1.

Performance

Weight Management

What to Expect

Week 1–2 Lipolytic signaling activated; fat mobilization starting. No dramatic feeling; fat loss process starting quietly.

Week 3–4 Measurable fat reduction; no impact on insulin or IGF-1. Belly fat starting to reduce; midsection feels tighter.

Week 5–8 Significant subcutaneous fat loss; body composition improving. Clearly losing fat without losing muscle.

Week 9–12 Peak lipolytic effect; lean physique consolidating. Lean and defined; visible six-pack territory for some.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier

LarnaLabs Verified Supplier · larnalabs.com

PepSpace Verified Supplier · pepspace.io

BioSynth Verified Custom Batch Supplier · biosynth.com

Peptide Sciences Unavailable · peptidesciences.com

Protocol & Dosage

Typical Dosage 250–500 mcg SC, 2x daily

Administration Subcutaneous injection

Schedule Twice daily: AM fasted and pre-bed

Protocol Duration 8–12 weeks

Half-Life ~30 minutes

Side Effects & Safety

Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

Injection site rednessmost users

Less Common

Headacheoccasional
Mild joint discomfortoccasional
Temporary drowsinessoccasional

Discontinue If

Severe allergic reaction (rash, swelling)
Persistent joint pain
Signs of elevated blood sugar

Contraindications

Active cancer or tumors
Pregnancy or breastfeeding
Poorly controlled diabetes

Data note: Lipolytic fragment of hGH without muscle-building or blood sugar effects. One of the better-tolerated GH-derived peptides.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about HGH Fragment 176-191

How to Apply

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

Sanitize

Wipe tops of both vials with alcohol swabs

Draw

Pull 1–2 mL of BAC water into syringe

Add Water

Release water slowly along vial wall, not directly on powder

Swirl

Roll between palms until dissolved. Never shake.

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for HGH Fragment 176-191

Also Known As HGH Frag 176-191, GH Fragment, Fat Fragment

Classification Peptide Fragment · Lipolytic

Sequence Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (C-terminal fragment of hGH)

Molecular Formula C₇₈H₁₂₅N₂₃O₂₃S₂

Molecular Weight 1,817.12 Da

CAS Number 221231-10-3

Half-Life ~30 minutes

Origin C-terminal fragment (aa 176-191) of human growth hormone

Administration Subcutaneous injection

Status Research compound

Mechanism of Action The specific slice of growth hormone responsible for fat burning, isolated from the rest. Tells fat cells to break down stored fat and stop making new fat, without affecting muscle growth, blood sugar, or IGF-1.

Research Overview HGH Fragment 176-191 is a synthetic peptide representing the C-terminal portion of human growth hormone, encompassing amino acid residues 176 through 191 of the 191-amino-acid GH polypeptide. The fragment was first characterized in the 1980s through domain-mapping studies that sought to identify which regions of the GH molecule were responsible for its diverse biological activities - growth promotion, lactogenic effects, diabetogenic properties, and lipolytic activity. These studies revealed that the C-terminal region of GH possesses intrinsic fat-mobilizing activity that is structurally and mechanistically distinct from the growth-promoting actions mediated through GH receptor binding and JAK2/STAT5 signaling at the N-terminal domain. The fragment does not bind the classical growth hormone receptor and therefore does not activate the GH-IGF-1 axis, produce insulin resistance, or stimulate cellular proliferation - properties that make it an attractive candidate for selective fat reduction without the metabolic complications of full-length GH therapy. Research by Ng and colleagues at Monash University in Melbourne demonstrated that HGH Fragment 176-191 stimulates lipolysis in isolated adipocytes through a mechanism involving beta-3 adrenergic receptor signaling and simultaneously inhibits lipogenesis (de novo fat synthesis), producing a dual anti-obesity effect that was confirmed in obese rodent models. The fragment also does not affect appetite, glucose homeostasis, or lean body mass, making its pharmacological profile highly specific for fat metabolism. The relationship between HGH Fragment 176-191 and AOD-9604 is worth noting - AOD-9604 is essentially a stabilized version of this fragment with a tyrosine residue added at the N-terminus to improve potency and stability. While HGH Fragment 176-191 has not been developed as a standalone pharmaceutical product, it has served as the basis for AOD-9604's development and continues to be widely used in research settings investigating the molecular mechanisms of GH-mediated lipolysis.

Citations

Published findings on HGH Fragment 176-191 from peer-reviewed journals.

Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

Ng FM, et al. • 2001 PubMed

Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism

Heffernan M, et al. • 2000 PubMed

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice

Heffernan MA, et al. • 2001 PubMed