NOT MEDICAL ADVICE

KPV

Estimated Market Price
$89.99 $104.99
Based on verified supplier pricing for research-grade compounds
Sequence: Lys-Pro-Val | MW: 342.43 g/mol | Purity: >=98% HPLC | Lyophilized powder, 10mg/vial
How it works

Enters cells and blocks NF-kB, a master switch for inflammation, shutting down production of key inflammatory molecules. Especially effective at calming gut inflammation and protecting the intestinal lining.

Recovery & Longevity

What to Expect
Days 1–3 NF-κB inhibition begins; initial inflammatory dampening. If you have gut issues, slight calming of symptoms.
Week 1–2 Pro-inflammatory cytokines declining; GI symptoms easing. Less bloating; digestive comfort improving.
Week 3–4 Significant anti-inflammatory effect; mucosal healing visible. Gut feels noticeably calmer; inflammation-related symptoms easing.
Week 5–8 Peak benefits; systemic inflammation markers normalized. Digestive health significantly better; overall inflammation down.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 200–400 mcg SC daily
Administration Subcutaneous injection, Oral, Topical
Schedule Once daily, AM on empty stomach
Protocol Duration 4–8 weeks
Half-Life Short (minutes)
Side Effects & Safety
Tolerability Profile Favorable

Very well tolerated; side effects are rare and mild

Common Side Effects

  • Mild GI discomfort (oral route)some users

Less Common

  • Injection site rednessoccasional
  • Headacheoccasional
  • Mild nauseaoccasional

Discontinue If

  • Severe allergic reaction
  • Persistent GI distress
  • Signs of immunosuppression (recurrent infections)

Contraindications

  • Pregnancy or breastfeeding
  • Active GI malignancy
  • Immunosuppressive therapy (consult physician)

Data note: Derived from alpha-MSH. Anti-inflammatory tripeptide with excellent tolerability in available studies. Limited formal clinical trial data.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about KPV
Send us a message

Call us
+1 (518) 327-4392
Business hours
Monday – Friday 9:00 AM – 6:00 PM EST
Saturday 10:00 AM – 2:00 PM EST
Sunday Closed

You can also reach us via or .

How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for KPV

Also Known As KPV Tripeptide, α-MSH(11-13)
Classification Tripeptide · Anti-Inflammatory
Sequence Lys-Pro-Val
Molecular Formula C₁₆H₃₀N₄O₄
Molecular Weight 342.43 Da
CAS Number 67727-97-3
Half-Life Short (minutes)
Origin C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH)
Administration Subcutaneous injection, Oral, Topical
Status Research compound
Mechanism of Action Enters cells and blocks NF-kB, a master switch for inflammation, shutting down production of key inflammatory molecules. Especially effective at calming gut inflammation and protecting the intestinal lining.
Research Overview KPV is a C-terminal tripeptide fragment (Lys-Pro-Val) derived from alpha-melanocyte-stimulating hormone (α-MSH), representing the minimal bioactive sequence responsible for the potent anti-inflammatory properties of the parent hormone. The discovery that the anti-inflammatory activity of α-MSH could be localized to its C-terminal tripeptide was first reported by Lipton and colleagues in the 1990s and represented an important advance because the full 13-amino-acid α-MSH peptide exerts its effects through melanocortin receptors (primarily MC1R and MC3R), which also mediate melanogenesis, adrenal function, and feeding behavior. In contrast, KPV appears to produce its anti-inflammatory effects through a mechanism that is at least partially independent of melanocortin receptor activation - the tripeptide has been shown to enter cells directly and interact with intracellular inflammatory signaling cascades, most notably inhibiting the nuclear translocation of NF-κB, the master transcription factor controlling the expression of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, and IL-8. Research by Dalmasso and colleagues demonstrated that KPV treatment of human colonocytes significantly reduced NF-κB activation and pro-inflammatory cytokine production in response to inflammatory stimuli. In animal models of inflammatory bowel disease, KPV showed remarkable efficacy - oral administration reduced colonic inflammation, decreased disease activity scores, and promoted mucosal healing in both acute and chronic colitis models, with efficacy comparable to or exceeding that of standard anti-inflammatory therapies. The peptide's small size, stability, and oral bioavailability represent significant advantages for therapeutic development. Beyond gastrointestinal inflammation, KPV has shown anti-inflammatory effects in dermal inflammation, periodontal disease, and lung injury models, suggesting broad therapeutic potential across multiple organ systems where NF-κB-driven inflammation plays a pathological role.

Citations

Published findings on KPV from peer-reviewed journals.

Research Assistant
Hey, I'm the PepSpace research assistant. Ask me anything about peptides and I'll do my best to help.