NOT MEDICAL ADVICE

NAD+

Estimated Market Price
$129.99 $144.99
Based on verified supplier pricing for research-grade compounds
Nicotinamide adenine dinucleotide for cellular energy, DNA repair, and longevity. The foundational molecule for healthy aging.
How it works

Replenishes NAD+, a coenzyme your cells need for energy production, DNA repair, and sirtuin activation. NAD+ levels drop roughly 50% between ages 40-60, and restoring them supports cellular repair processes across the body.

Energy

Recovery & Longevity

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What to Expect
Days 1–3 IV: immediate energy boost and mental clarity post-infusion. IV: immediate mental clarity and energy boost after infusion.
Week 1–2 Cellular NAD+ levels rising; improved sleep and recovery. Sleeping better; waking up more refreshed and alert.
Week 3–4 Sirtuin activation measurable; sustained energy throughout day. Sustained energy through the day; no afternoon crashes.
Month 2–3 DNA repair pathways optimized; visible anti-aging markers improving. Looking and feeling younger; skin and recovery improving.
Month 4+ Maintenance phase; continued cellular rejuvenation benefits. Benefits feel like your new normal.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 250–500 mg/day IV or oral
Administration Intravenous infusion, Subcutaneous injection
Schedule Daily; IV sessions 1–3x/week, oral daily
Protocol Duration Ongoing (cycling optional)
Half-Life ~1-4 hours (IV infusion)
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Flushing during IV infusionmost users (IV)
  • Chest tightness or pressure (IV)some users (IV)
  • Mild nauseasome users

Less Common

  • Headacheoccasional
  • Muscle crampingoccasional
  • Temporary anxiety during infusionoccasional
  • Abdominal discomfortoccasional

Rare / Serious

  • Heart palpitationsrare
  • Insomnia (if administered late in day)rare

Discontinue If

  • Severe chest pain or shortness of breath
  • Persistent muscle cramping or pain
  • Signs of anaphylaxis

Contraindications

  • Active cancer or tumors (NAD fuels rapidly dividing cells)
  • Severe liver or kidney disease
  • Pregnancy or breastfeeding

Data note: Essential coenzyme found in all living cells. IV infusion side effects are rate-dependent and resolve by slowing infusion speed.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about NAD+
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for NAD+

Also Known As NAD+, Nicotinamide Adenine Dinucleotide, Coenzyme I
Classification Dinucleotide Coenzyme · Anti-Aging
Sequence N/A (dinucleotide coenzyme)
Molecular Formula C₂₁H₂₇N₇O₁₄P₂
Molecular Weight 663.43 Da
CAS Number 53-84-9
Half-Life ~1-4 hours (IV infusion)
Origin Essential coenzyme found in all living cells
Administration Intravenous infusion, Subcutaneous injection
Status Research · Available as supplement (NMN/NR precursors)
Mechanism of Action Replenishes NAD+, a coenzyme your cells need for energy production, DNA repair, and sirtuin activation. NAD+ levels drop roughly 50% between ages 40-60, and restoring them supports cellular repair processes across the body.
Research Overview Nicotinamide adenine dinucleotide (NAD+) is a coenzyme of central importance in cellular metabolism, functioning as an electron carrier in over 500 enzymatic reactions and serving as a substrate for several families of signaling enzymes that regulate processes from DNA repair to circadian rhythms. First described by Arthur Harden and William John Young in 1906 during their investigations into fermentation, and subsequently identified as a dinucleotide by Hans von Euler-Chelpin in the 1930s, NAD+ has experienced a dramatic resurgence of scientific interest in the 21st century driven primarily by the discovery of its critical role as a substrate for sirtuin enzymes (SIRT1-7) and poly-ADP-ribose polymerases (PARPs). Sirtuins are NAD+-dependent deacylases that regulate a vast network of metabolic and stress-response pathways - SIRT1 deacetylates transcription factors including PGC-1α, FOXO proteins, and p53 to enhance mitochondrial biogenesis, antioxidant defense, and DNA repair. PARPs consume large quantities of NAD+ during DNA damage repair, and under conditions of chronic genotoxic stress, PARP hyperactivation can deplete cellular NAD+ pools to levels that compromise sirtuin function and cellular energy metabolism. The landmark finding by Shin-ichiro Imai and colleagues that NAD+ levels decline approximately 50% between ages 40 and 60 in human tissues catalyzed a wave of research into NAD+ restoration as an anti-aging strategy. Preclinical studies in aged mice demonstrated that supplementation with NAD+ precursors (NMN or NR) could reverse age-associated physiological decline in muscle, vasculature, and neurological function. Human clinical trials of intravenous NAD+ infusion and oral precursor supplementation are ongoing, with early results showing successful elevation of blood NAD+ levels, improvements in mitochondrial function markers, and enhanced physical performance in older adults, though definitive evidence of lifespan extension or age-reversal in humans remains to be established.

Citations

Published findings on NAD+ from peer-reviewed journals.

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