NOT MEDICAL ADVICE

Palmitoyl Tripeptide-1

Estimated Market Price
$69.99 $84.99
Based on verified supplier pricing for research-grade compounds
Collagen-mimicking signal peptide that triggers skin repair. Enhanced penetration via palmitoyl group. Core component of Matrixyl 3000 formulations.
How it works

Carries the same collagen-boosting GHK sequence found in GHK-Cu, with a palmitoyl tail for deeper skin penetration. Signals fibroblasts to produce more collagen I and III, firming skin and reducing fine lines.

Skin & Beauty

What to Expect
Week 1–2 GHK fragment penetrating dermis; fibroblast activation starting. Skin feels a bit more hydrated and smooth.
Week 3–4 Collagen I and III synthesis rising; skin firming beginning. Firmness improving; skin starting to feel tighter.
Week 5–8 Visible reduction in fine lines; improved skin elasticity. Fine lines fading; skin looks plumper and healthier.
Week 9–12 Peak collagen rebuilding; significantly firmer, smoother skin. Visibly firmer, more youthful-looking skin.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage Topical serum, 2x daily
Administration Topical
Schedule Morning and evening to clean, dry skin
Protocol Duration 8–12 weeks
Half-Life Topical application
Side Effects & Safety
Tolerability Profile Favorable

Very well tolerated; side effects are rare and mild

Common Side Effects

  • No common side effects reported

Less Common

  • Mild skin irritationoccasional
  • Temporary rednessoccasional

Discontinue If

  • Severe allergic reaction
  • Persistent skin irritation or sensitization

Contraindications

  • Known hypersensitivity to palmitoyl peptides
  • Active skin infection at application site
  • Open wounds at application site

Data note: Collagen-signaling peptide used in premium skincare. Long safety record in cosmetic formulations.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Palmitoyl Tripeptide-1
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How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Palmitoyl Tripeptide-1

Also Known As Pal-GHK, Palmitoyl Oligopeptide, Biopeptide CL
Classification Lipopeptide · Collagen Stimulator / Cosmetic
Sequence Pal-Gly-His-Lys
Molecular Formula C₃₀H₅₄N₆O₅
Molecular Weight 578.79 Da
CAS Number 147732-56-7
Half-Life Topical application
Origin Synthetic lipopeptide based on the GHK fragment of collagen
Administration Topical
Status Commercially available - cosmetic ingredient
Mechanism of Action Carries the same collagen-boosting GHK sequence found in GHK-Cu, with a palmitoyl tail for deeper skin penetration. Signals fibroblasts to produce more collagen I and III, firming skin and reducing fine lines.
Research Overview Palmitoyl Tripeptide-1 (Pal-GHK, also marketed as Biopeptide CL) is a synthetic lipopeptide consisting of the tripeptide Gly-His-Lys conjugated to a palmitic acid (C16:0) acyl chain, developed as a collagen-stimulating cosmeceutical ingredient based on the matrikine signaling concept. The GHK tripeptide sequence is the same biologically active fragment found in GHK-Cu (copper peptide), originally identified by Loren Pickart as a plasma factor capable of stimulating tissue rejuvenation. Without the copper ion, the GHK sequence retains its ability to act as a matrikine - a small peptide fragment released during extracellular matrix degradation that functions as a signaling molecule to coordinate tissue repair and remodeling. GHK specifically signals fibroblasts to increase the synthesis of collagen I, collagen III, fibronectin, and glycosaminoglycans, effectively mimicking the natural feedback signal that would be generated during collagen turnover. The addition of the palmitoyl lipid tail serves a dual purpose - it dramatically enhances the peptide's ability to penetrate the stratum corneum (the outermost layer of skin), which acts as a formidable barrier to hydrophilic molecules, and it may also improve interaction with cell membrane lipid bilayers, potentially enhancing receptor recognition and cellular uptake. In vitro studies on human dermal fibroblast cultures demonstrated that Palmitoyl Tripeptide-1 treatment increased procollagen I synthesis by up to 350% compared to untreated controls, an effect mediated through TGF-β pathway activation and Smad2/3 nuclear translocation. The peptide is frequently combined with Palmitoyl Tetrapeptide-7 (a complementary anti-inflammatory peptide that reduces IL-6 secretion) in a proprietary complex marketed as Matrixyl 3000, which targets both the collagen synthesis and inflammatory degradation aspects of skin aging simultaneously.

Citations

Published findings on Palmitoyl Tripeptide-1 from peer-reviewed journals.

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