Pinealon

Estimated Market Price

$79.99 – $94.99

Based on verified supplier pricing for research-grade compounds

Brain-derived tripeptide bioregulator. Protects neurons from oxidative stress, enhances mitochondrial function, and supports cognitive longevity.

How it works

Small enough to enter cell nuclei and directly influence gene expression related to brain protection. Boosts antioxidant defenses in neural tissue, promotes melatonin production, and shields neurons from low-oxygen and oxidative damage.

Focus & Cognition

Longevity

What to Expect

Days 1–3 DNA-level gene modulation initiating; melatonin synthesis rising. May notice slightly better sleep onset.

Week 1 Neuroprotective gene expression active; sleep quality improving. Sleep deepening; waking up feeling more refreshed.

Week 2 Antioxidant defense enhanced; cognitive clarity sharpening. Thinking feels clearer; less mental fog throughout the day.

Week 3–4 Peak bioregulatory effects; neuronal protection optimized. Overall cognitive sharpness and sleep quality improved.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier

LarnaLabs Verified Supplier · larnalabs.com

PepSpace Verified Supplier · pepspace.io

BioSynth Verified Custom Batch Supplier · biosynth.com

Peptide Sciences Unavailable · peptidesciences.com

Protocol & Dosage

Typical Dosage 10 mg daily oral or intranasal

Administration Oral, Subcutaneous injection

Schedule Once daily, AM preferred

Protocol Duration 2–4 weeks

Half-Life Short

Side Effects & Safety

Tolerability Profile Favorable

Very well tolerated; side effects are rare and mild

Common Side Effects

No common side effects reported

Less Common

Mild drowsinessoccasional
Headacheoccasional
Vivid dreamsoccasional

Discontinue If

Worsening insomnia or sleep disruption
Mood changes or depression
Severe allergic reaction

Contraindications

Pregnancy or breastfeeding
Concurrent sedative use
Severe depression or suicidal ideation

Data note: Short tripeptide bioregulator (EDR). Very well tolerated in available studies. Limited Western clinical data.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Pinealon

How to Apply

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

Sanitize

Wipe tops of both vials with alcohol swabs

Draw

Pull 1–2 mL of BAC water into syringe

Add Water

Release water slowly along vial wall, not directly on powder

Swirl

Roll between palms until dissolved. Never shake.

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Pinealon

Also Known As Pinealon, EDR Peptide

Classification Tripeptide · Neuroprotective / Bioregulator

Sequence Glu-Asp-Arg

Molecular Formula C₁₃H₂₂N₄O₈

Molecular Weight 404.38 Da

CAS Number 148898-39-3

Half-Life Short

Origin Synthetic tripeptide bioregulator based on pineal gland peptides

Administration Oral, Subcutaneous injection

Status Research compound - available as supplement in some countries

Mechanism of Action Small enough to enter cell nuclei and directly influence gene expression related to brain protection. Boosts antioxidant defenses in neural tissue, promotes melatonin production, and shields neurons from low-oxygen and oxidative damage.

Research Overview Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg (glutamic acid-aspartic acid-arginine) developed by Professor Vladimir Khavinson's research group at the Saint Petersburg Institute of Bioregulation and Gerontology as a synthetic analog of peptides naturally produced by the pineal gland that was designed to exert neuroprotective and neuroregulatory effects. Like other peptides in the Khavinson bioregulator series, pinealon is proposed to function through a mechanism of direct interaction with DNA - the tripeptide is small enough to pass through both cell membranes and nuclear membranes without requiring receptor-mediated transport, and crystallographic and molecular modeling studies have suggested that it can bind to specific nucleotide sequences in the minor groove of double-stranded DNA, potentially modulating the expression of genes involved in neuronal protection and function. In vitro studies have demonstrated that pinealon treatment of cortical neuron cultures subjected to oxidative stress with hydrogen peroxide or hypoxic conditions significantly increased cell viability and reduced markers of apoptosis compared to untreated controls. The peptide has been shown to enhance the expression of antioxidant enzymes including superoxide dismutase and catalase in brain tissue, and to promote melatonin synthesis in pinealocyte cultures, suggesting a functional link to the pineal gland's endocrine output. Animal studies in aged rodents demonstrated that pinealon administration improved cognitive performance in maze learning tasks, reduced anxiety-like behavior, and normalized age-related changes in electroencephalographic patterns. The peptide has also been studied in models of cerebral ischemia, where pre-treatment reduced infarct volume and improved neurological function scores. Pinealon is available as a dietary supplement in Russia and some other countries, and is part of a broader category of "cytomax" peptide bioregulators that includes organ-specific preparations for the thymus (thymalin), retina (retinalamin), prostate (prostatilen), and other tissues.

Citations

Published findings on Pinealon from peer-reviewed journals.

Pinealon Increases Cell Viability by Suppression of Free Radical Levels and Activating Proliferative Processes

Khavinson V, et al. • 2011 PubMed

Pinealon protects the rat offspring from prenatal hyperhomocysteinemia

Arutjunyan AV, et al. • 2012 PubMed

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer Disease

Khavinson V, et al. • 2021 PubMed