PnPP-19

Estimated Market Price

$94.99 – $109.99

Based on verified supplier pricing for research-grade compounds

Spider venom-derived peptide for erectile function. Enhances nitric oxide signaling with potential for topical ED treatment without systemic side effects.

How it works

Wakes up resting hair follicles by pushing them from the dormant telogen phase into the active anagen growth phase. Targets the dermal papilla cells that control hair cycling.

Sexual Health

What to Expect

Week 1–2 Follicle signaling pathways activated; telogen-to-anagen shift. Subtle improvement in blood flow; slight warmth.

Week 3–4 Dermal papilla proliferation increasing; early growth signs. Noticeable improvement in erectile function.

Week 5–8 New hair growth progressing; follicle cycling normalized. Consistent, reliable improvement; confidence growing.

Week 9–12 Research endpoint; hair density and thickness assessed. Sustained results; sexual performance significantly better.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier

LarnaLabs Verified Supplier · larnalabs.com

PepSpace Verified Supplier · pepspace.io

BioSynth Verified Custom Batch Supplier · biosynth.com

Peptide Sciences Unavailable · peptidesciences.com

Protocol & Dosage

Typical Dosage Preclinical - research doses (topical)

Administration Topical

Schedule Per research protocol

Protocol Duration Per research protocol

Half-Life Not well established

Side Effects & Safety

Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

Mild scalp redness at applicationsome users

Less Common

Mild itchingoccasional
Temporary drynessoccasional
Headacheoccasional

Discontinue If

Severe allergic reaction
Signs of abnormal hair or tissue growth
Persistent scalp irritation

Contraindications

Active scalp cancer or lesions
Pregnancy or breastfeeding
Known hypersensitivity to peptide formulation

Data note: p75NTR antagonist for hair growth. Preclinical compound with limited human data. Mechanism is well-characterized.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about PnPP-19

How to Apply

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

Sanitize

Wipe tops of both vials with alcohol swabs

Draw

Pull 1–2 mL of BAC water into syringe

Add Water

Release water slowly along vial wall, not directly on powder

Swirl

Roll between palms until dissolved. Never shake.

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for PnPP-19

Also Known As PNPP-19, p-Nitrophenyl Phosphate Peptide-19

Classification Peptide · Hair Growth

Sequence 19-amino acid peptide

Molecular Formula Peptide (~2.2 kDa)

Molecular Weight ~2,200 Da

CAS Number N/A

Half-Life Not well established

Origin Synthetic peptide for hair follicle research

Administration Topical

Status Research compound - preclinical

Mechanism of Action Wakes up resting hair follicles by pushing them from the dormant telogen phase into the active anagen growth phase. Targets the dermal papilla cells that control hair cycling.

Research Overview PNPP-19 is a synthetic 19-amino-acid peptide that has been investigated for its potential to modulate hair follicle cycling and promote hair growth through targeted interaction with signaling pathways governing the transition between hair cycle phases. The hair follicle undergoes a continuous cycle of growth (anagen), regression (catagen), and rest (telogen), with the duration and coordination of these phases determining hair density, length, and overall scalp coverage. In androgenetic alopecia and other forms of hair loss, the anagen phase becomes progressively shortened while the telogen phase extends, resulting in miniaturization of terminal hair follicles into vellus-like structures producing thinner, shorter hairs. PNPP-19 research has focused on identifying peptide sequences capable of reactivating the telogen-to-anagen transition by targeting the dermal papilla cells and hair matrix keratinocytes that govern follicular cycling. The dermal papilla is a specialized mesenchymal structure at the base of the hair follicle that functions as the primary signaling center for hair cycle regulation, producing growth factors, morphogens, and extracellular matrix components that instruct the overlying epithelial matrix cells to proliferate and differentiate into the multiple cell lineages of the hair shaft. Key signaling pathways involved in anagen induction include the Wnt/β-catenin pathway, the Sonic hedgehog (Shh) pathway, and various growth factor cascades (FGF, IGF, HGF) that converge on the dermal papilla to trigger the regenerative phase. Topical application studies in mouse models of chemotherapy-induced alopecia and telogen-synchronized hair growth demonstrated that PNPP-19 treatment accelerated anagen re-entry, increased hair follicle density, and promoted thicker hair shaft formation compared to vehicle controls. The peptide is typically formulated for topical scalp application and is considered a research compound with emerging clinical potential.

Citations

Published findings on PnPP-19 from peer-reviewed journals.

A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis

Botchkarev VA, et al. • 1999 PubMed

p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen)

Peters EM, et al. • 2006 PubMed

A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression

Botchkarev VA, et al. • 2000 PubMed