NOT MEDICAL ADVICE

Semax

Estimated Market Price
$84.99 $99.99
Based on verified supplier pricing for research-grade compounds
Neuropeptide for cognitive enhancement, memory, and neuroprotection. The brain-performance peptide used by professionals worldwide.
How it works

Ramps up BDNF and NGF production to protect neurons and sharpen cognitive function, memory, and focus. Works through serotonin and dopamine pathways without the hormonal side effects of its parent molecule ACTH.

Focus & Cognition

bestseller

What to Expect
Days 1–3 Acute cognitive clarity; improved focus within hours of dosing. Mental fog lifts within hours; thoughts feel sharper.
Week 1 BDNF and NGF levels rising; memory consolidation improving. Remembering things more easily; conversations flow better.
Week 2 Sustained attention and verbal fluency noticeably enhanced. Can focus for longer stretches; mental stamina increased.
Week 3–4 Peak neuroprotective benefits; optimal cognitive performance. Brain feels "on"; learning new things comes faster.

Verified Suppliers

For research purposes only. These suppliers have been independently verified by PepSpace. We do not process sales directly.

PepSpace is not affiliated with any listed supplier
Protocol & Dosage
Typical Dosage 200–600 mcg/day intranasal
Administration Intranasal
Schedule Once or twice daily, AM preferred
Protocol Duration 2–4 weeks
Half-Life Minutes (nasal extends effective duration to hours)
Side Effects & Safety
Tolerability Profile Mild

Generally well tolerated; side effects are mild and transient

Common Side Effects

  • Nasal irritation or mild burningmost users
  • Mild headachesome users

Less Common

  • Temporary restlessness or overstimulationoccasional
  • Mild facial flushingoccasional
  • Insomnia (if taken late in day)occasional

Rare / Serious

  • Elevated blood pressurerare
  • Irritabilityrare

Discontinue If

  • Severe headache or visual disturbances
  • Heart palpitations or chest tightness
  • Persistent elevated blood pressure

Contraindications

  • Uncontrolled hypertension
  • Pregnancy or breastfeeding
  • History of seizure disorders

Data note: Approved in Russia and Ukraine since 1994 for stroke and cognitive disorders. Thousands of patients treated over 30 years.

Always consult a qualified healthcare professional before use. This information is for research reference only and does not constitute medical advice.

Ask about Semax
Send us a message

Call us
+1 (518) 327-4392
Business hours
Monday – Friday 9:00 AM – 6:00 PM EST
Saturday 10:00 AM – 2:00 PM EST
Sunday Closed

You can also reach us via or .

How to Apply

1

Gather

Peptide vial, BAC water, alcohol swabs, insulin syringe

2

Sanitize

Wipe tops of both vials with alcohol swabs

3

Draw

Pull 1–2 mL of BAC water into syringe

4

Add Water

Release water slowly along vial wall, not directly on powder

5

Swirl

Roll between palms until dissolved. Never shake.

6

Store

Refrigerate 2–8°C, use within 30 days

Frequently Asked Questions

Yes. Bacteriostatic water (BAC water) is required to reconstitute lyophilized (freeze-dried) peptides. It contains 0.9% benzyl alcohol which prevents bacterial growth, keeping your reconstituted peptide safe for multiple uses over up to 30 days.

Unreconstituted: store at -20°C (freezer) for long-term, or 2–8°C (fridge) for short-term. After reconstitution: always refrigerate at 2–8°C and use within 30 days. Keep away from direct sunlight.

Results vary by individual and protocol. In research settings, measurable effects are typically observed within 1–4 weeks depending on the specific peptide, dosage, and application. Consult a qualified professional for guidance.

Verified suppliers typically include a full third-party COA verifying purity (99%+), identity, and sterility. We recommend only sourcing from vendors that provide batch-specific testing data.

We list verified suppliers above that have been independently reviewed for product quality, testing transparency, and shipping reliability. Always verify COA data before sourcing.

Compound Profile

Scientific data & classification for Semax

Also Known As ACTH(4-7)-PGP, Semax 1%
Classification Heptapeptide · Nootropic / Neuroprotective
Sequence Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula C₃₇H₅₁N₉O₁₀S
Molecular Weight 813.93 Da
CAS Number 80714-61-0
Half-Life Minutes (nasal extends effective duration to hours)
Origin Synthetic analog of ACTH(4-10) with Pro-Gly-Pro C-terminal extension
Administration Intranasal
Status Approved in Russia and Ukraine - nootropic / neuroprotective
Mechanism of Action Ramps up BDNF and NGF production to protect neurons and sharpen cognitive function, memory, and focus. Works through serotonin and dopamine pathways without the hormonal side effects of its parent molecule ACTH.
Research Overview Semax is a synthetic heptapeptide nootropic and neuroprotective agent developed in the late 1980s at the Institute of Molecular Genetics of the Russian Academy of Sciences, primarily through the work of Nikolai Myasoedov and colleagues. The peptide is based on the ACTH(4-7) fragment - Met-Glu-His-Phe - which retains the neurotrophic and nootropic properties of the full adrenocorticotropic hormone without its hormonal (steroidogenic) effects, extended with a Pro-Gly-Pro tripeptide at the C-terminus to improve metabolic stability. Semax was approved for medical use in Russia and Ukraine in 1994 and has been prescribed for a range of neurological conditions including ischemic stroke, cognitive impairment, peptic ulcer disease, and optic nerve atrophy. The neuroprotective mechanism is multifaceted - semax robustly upregulates the expression of BDNF and its high-affinity receptor trkB in the hippocampus and cortex, stimulates nerve growth factor (NGF) expression, and activates survival signaling cascades including the MAPK/ERK and PI3K/Akt pathways. In models of cerebral ischemia, semax administration within hours of the ischemic event significantly reduced infarct volume and improved functional neurological outcomes, with transcriptomic analyses revealing that the peptide modulated the expression of over 1,800 genes related to immune response, vascular function, and neuronal survival. The compound also influences monoaminergic neurotransmission, increasing the turnover of serotonin, dopamine, and their metabolites in specific brain regions, which likely contributes to its effects on mood, attention, and memory consolidation. An important pharmacological advantage of semax is its excellent intranasal bioavailability, allowing non-invasive administration that bypasses the blood-brain barrier via olfactory and trigeminal nerve transport pathways. Clinical experience in Russia over three decades encompasses thousands of patients with stroke, traumatic brain injury, and cognitive disorders, though controlled clinical trial data that meets Western regulatory standards remains limited.

Citations

Published findings on Semax from peer-reviewed journals.

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